Dr. Adrian Schröder

Background

  • since 01/2007 research assistant at the Centre for Bioinformatics (ZBIT), University of Tübingen
  • 10/2000-10/2006 Computer science student at the University of Tübingen
  • 01/2005-10/2006 assistant at Synovo GmbH

 

Research Interests

  • Data mining and modelling in systems biology
  • New approaches to pharmacogenomics and systems genetics
  • Machine learning bases methods for transcription factor binding site prediction and cis-regulatory module detection
  • Data and knowledge based inference of gene regulatory mechanisms
  • Dynamic modeling of complex biochemical systems

 

Current Projects

  • Virtual Liver: Subproject A3.4: Linking signaling to metabolic functions; subproject B5: Impact of cytokines on detoxifying functions in primary human hepatocytes
  • Genomics of ADME gene expression: Mapping quantitative trait loci relevant for absorption, distribution, metabolism and excretion of drugs
  • MARCAR: bioMARkers and molecular tumor classification for non-genotoxic CARcinogenesis
  • Spher4Sys: Systems biology based approach for preclinical lead compound development using an in-vivo like spheroid test system
  • HepatoSys: A systems biology approach to decipher statin-induced gene regulatory mechanisms in primary human hepatocytes

 

Publications

[1] Adrian Schröder. Inference of gene-regulatory networks in primary human hepatocytes. PhD thesis, University of Tuebingen, Tübingen, Germany, November 2011. [ details | link ]
[2] Adrian Schröder, Kathrin Klein, Stefan Winter, Matthias Schwab, Michael Bonin, Andreas Zell, and Ulrich M. Zanger. Genomics of ADME gene expression: mapping expression quantitative trait loci relevant for absorption, distribution, metabolism and excretion of drugs in human liver. The Pharmacogenomics Journal, pages 1473-1150, September 2011. [ DOI | details | link | pdf ]
[3] Finja Büchel, Clemens Wrzodek, Florian Mittag, Andreas Dräger, Adrian Schröder, and Andreas Zell. ProDGe: investigating protein-protein interactions at the domain level. Technical report, Nature Precedings, August 2011. [ DOI | details | link | pdf ]
[4] Adrian Schröder, Johannes Wollnik, Clemens Wrzodek, Andreas Dräger, Michael Bonin, Oliver Burk, Maria Thomas, Wolfgang E. Thasler, Ulrich M. Zanger, and Andreas Zell. Inferring statin-induced gene regulatory relationships in primary human hepatocytes. Bioinformatics, 27(18):2473-2477, July 2011. [ DOI | details | link | pdf ]
[5] Adrian Schröder, Clemens Wrzodek, Johannes Wollnik, Andreas Dräger, Dierk Wanke, Kenneth W. Berendzen, and Andreas Zell. Inferring transcriptional regulators for sets of co-expressed genes by multi-objective evolutionary optimization. In IEEE Congress on Evolutionary Computation (CEC 2011), New Orleans, USA, June 2011. IEEE. [ DOI | details | link | pdf ]
[6] Adrian Schröder, Johannes Eichner, Jochen Supper, Jonas Eichner, Dierk Wanke, Carsten Henneges, and Andreas Zell. Predicting DNA-Binding Specificities of Eukaryotic Transcription Factors. PLoS ONE, 5(11):e13876, November 2010. [ DOI | details | link | pdf ]
[7] Andreas Dräger, Adrian Schröder, and Andreas Zell. Systems Biology for Signaling Networks, volume 1 of Systems Biology, chapter Automating mathematical modeling of biochemical reaction networks, pages 159-205. Springer-Verlag, July 2010. [ DOI | details | link ]
[8] Clemens Wrzodek, Adrian Schröder, Andreas Dräger, Dierk Wanke, Kenneth W. Berendzen, Marcel Kronfeld, Klaus Harter, and Andreas Zell. ModuleMaster: A new tool to decipher transcriptional regulatory networks. Biosystems, 99(1):79-81, January 2010. [ DOI | details | link | pdf ]
[9] Jochen Supper, Lucía Spangenberg, Hannes Planatscher, Andreas Dräger, Adrian Schröder, and Andreas Zell. BowTieBuilder: modeling signal transduction pathways. BMC Systems Biology, 3(1):67, June 2009. [ DOI | details | link | pdf ]
[10] Andreas Dräger, Hannes Planatscher, Dieudonné Motsou Wouamba, Adrian Schröder, Michael Hucka, Lukas Endler, Martin Golebiewski, Wolfgang Müller, and Andreas Zell. SBML2LATEX: Conversion of SBML files into human-readable reports. Bioinformatics, 25(11):1455-1456, April 2009. [ DOI | details | link | pdf ]
[11] Andreas Dräger, Nadine Hassis, Jochen Supper, Adrian Schröder, and Andreas Zell. SBMLsqueezer: a CellDesigner plug-in to generate kinetic rate equations for biochemical networks. BMC Systems Biology, 2(1):39, April 2008. [ DOI | details | link | pdf ]

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Theses

[1] Adrian Schröder. Inference of gene-regulatory networks in primary human hepatocytes. PhD thesis, University of Tuebingen, Tübingen, Germany, November 2011. [ details ]
[2]
Integration of CH - PI Interactions into a grid based genetic docking algorithm
Studienarbeit, University of Tübingen, 2005
[3]
Construction of a Dynamic Model of the T-Cell Signal Transduction
Master thesis, University of Tübingen, 2006

 

Address, Phone, Fax, Email

Eberhard-Karls-Universität Tübingen
Wilhelm-Schickard-Institut für Informatik
Lehrstuhl Kognitive Systeme
Sand 1
D - 72076 Tübingen
 
Germany

Tel: (+49/0) 7071 / 29 70436
Fax: (+49/0) 7071 / 29 5091
Email: